Recent applications of basophil activation tests in the diagnosis of drug hypersensitivity

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Recent applications of basophil activation tests in the diagnosis of drug hypersensitivity

Immediate-type drug hypersensitivity is an increasingly significant clinical issue; however, the diagnosis is frequently hindered due to lack of safe and precise diagnostic tests. Flow cytometry-assisted basophil activation test is a safe in vitro diagnostic tool for assessing basophil activation upon allergen stimulation. In this review, we have summarized current literature on the diagnostic ...

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In vitro Tests: Basophil Activation Tests

In recent years, the quantification of basophil activation by flow cytometry (basophil activation test, BAT) has proven to be a useful tool for the assessment of immediate-type responses to allergens mediated by IgE or other mechanisms in drug-allergic patients. To date, most BAT studies reported in the literature have used CD69 or CD203c as markers to quantify basophil activation after antigen...

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ژورنال

عنوان ژورنال: Asia Pacific Allergy

سال: 2013

ISSN: 2233-8276,2233-8268

DOI: 10.5415/apallergy.2013.3.4.266